Soman increases neuronal COX-2 levels: Possible link between seizures and protracted neuronal damage
نویسندگان
چکیده
منابع مشابه
A molecular link between distinct neuronal asymmetries
Striking functional lateralization of the human brain across the left–right axis has long been known, the most notable of which is the localization of language to the left side of the brain. Mechanisms used to establish brain asymmetry have remained elusive due to the difficulty of identifying molecular correlates of functional asymmetries. The nematode Caenorhabditis ele‐ gans has been a valua...
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Neurons respond to numerous factors in their environment that influence their survival and function during development and in the mature brain. Among these factors, the neurotrophins have been shown to support neuronal survival and function, acting primarily through the Trk family of receptor tyrosine kinases. However, recent studies have established that the uncleaved neurotrophin precursors, ...
متن کاملMechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2.
Commentary It is well established that seizures, particularly status epilepti-cus (SE), induce upregulation of cyclooxygenase-2 (COX-2) in both neurons and non-neuronal cells (1, 2). COX-2 plays a role in seizure-induced leukocyte infiltration, astrogliosis, microg-lial activation, and breakdown of the blood-brain barrier (BBB); thus, COX-2 is clearly an important component of brain inflammatio...
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Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cere...
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Although stress represents the major environmental element of susceptibility for mood disorders, the relationship between stress and disease remains to be fully established. In the present article we review the evidence in support for a role of neuronal plasticity, and in particular of neurotrophic factors. Even though decreased levels of norepinephrine and serotonin may underlie depressive sym...
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ژورنال
عنوان ژورنال: NeuroToxicology
سال: 2010
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2010.06.007